Sorting signals
نویسندگان
چکیده
منابع مشابه
Sorting out Toll Signals
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there i...
متن کاملPrediction of N-terminal protein sorting signals.
Recently, neural networks have been applied to a widening range of problems in molecular biology. An area particularly suited to neural-network methods is the identification of protein sorting signals and the prediction of their cleavage sites, as these functional units are encoded by local, linear sequences of amino acids rather than global 3D structures.
متن کاملSignals for sorting of transmembrane proteins to endosomes and lysosomes.
Sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present within the cytosolic domains of the proteins. Most signals consist of short, linear sequences of amino acid residues. Some signals are referred to as tyrosine-based sorting signals and conform to the NPXY or YXXO consensus motifs. Other signals known as dileucine-based signals fit [DE]XXXL[LI] or DXXLL c...
متن کاملExtensive feature detection of N-terminal protein sorting signals
MOTIVATION The prediction of localization sites of various proteins is an important and challenging problem in the field of molecular biology. TargetP, by Emanuelsson et al. (J. Mol. Biol., 300, 1005-1016, 2000) is a neural network based system which is currently the best predictor in the literature for N-terminal sorting signals. One drawback of neural networks, however, is that it is generall...
متن کاملSorting continuous-time signals: analog median and median-type filters
There are two natural orderings in signals: temporal order and rank order. There is no compelling reason to explore only one of these orderings, either in the discrete-time or in the continuous-time case. Nevertheless, the concept of rank order for continuous-time signals remains virtually unstudied, which is in striking contrast to the discrete-time case: ranked order discrete-time filters, of...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 1989
ISSN: 0955-0674
DOI: 10.1016/0955-0674(89)90024-0